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Table 3 Combination index values of AZD-1775 in combination with bosutinib isomer (Bos-I) on BCR-ABL1-negative cell lines

From: Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

   

24 h

48 h

72 h

Bosutinib isomer (nM)

Bosutinib isomer (nM)

Bosutinib isomer (nM)

Cell line

500

1000

2000

500

1000

2000

500

1000

2000

NALM-6

AZD-1775 (nM)

6.9

0.57

0.69

0.79

0.62

1.00

1.21

0.59

0.79

1.14

20.6

0.33

0.48

0.64

0.65

0.81

1.07

0.47

0.68

0.99

61.7

0.35

0.39

0.65

0.67

0.65

0.97

0.68

0.73

0.93

185.2

0.48

0.41

0.41

0.91

0.65

0.68

0.89

0.73

0.63

555.6

0.63

0.43

0.36

0.54

0.45

0.47

0.41

0.40

0.48

1666.7

0.67

0.51

0.41

0.65

0.66

0.68

0.53

0.59

0.66

5000.0

1.65

1.43

1.21

1.58

1.61

1.62

1.42

1.43

1.52

Cell lines

250

500

1000

250

500

1000

250

500

1000

NALM-19

AZD-1775 (nM)

6.9

0.43

0.75

1.01

1.99

2.94

0.20

0.19

0.28

0.35

20.6

0.38

0.47

0.63

1.53

1.15

0.12

0.24

0.29

0.28

61.7

0.19

0.27

0.23

0.20

0.12

0.09

0.44

0.48

0.31

185.2

0.27

0.24

0.24

0.42

0.23

0.15

0.67

0.48

0.26

555.6

0.38

0.31

0.28

0.41

0.31

0.25

0.29

0.28

0.21

1666.7

0.76

0.68

0.69

0.82

0.72

0.69

0.47

0.44

0.38

5000.0

1.78

1.95

1.77

2.04

2.09

1.93

1.19

1.30

1.13

MOLT-4

AZD-1775 (nM)

6.9

1.23

0.93

1.11

0.99

1.03

1.28

0.67

1.22

1.26

20.6

0.78

0.61

0.78

0.85

0.89

1.07

0.74

0.89

1.07

61.7

0.77

0.53

0.43

0.62

0.63

0.71

0.91

0.85

0.77

185.2

0.53

0.40

0.23

0.39

0.35

0.34

0.35

0.37

0.53

555.6

0.22

0.25

0.21

0.34

0.40

0.50

0.35

0.43

0.67

1666.7

0.40

0.60

0.65

0.95

1.12

1.14

0.92

0.96

1.17

5000.0

2.46

2.25

3.02

3.06

3.26

3.49

3.54

3.30

3.52

Cell line

2000

5000

10000

2000

5000

10000

2000

5000

10000

CCRF-CEM

AZD-1775 (nM)

6.9

0.75

0.78

0.84

0.75

0.78

0.84

1.06

0.65

0.39

20.6

0.38

0.62

0.79

0.38

0.62

0.79

1.21

0.57

0.52

61.7

0.27

0.54

0.74

0.27

0.54

0.74

0.53

0.49

0.52

185.2

0.26

0.46

0.58

0.26

0.46

0.58

0.28

0.43

0.49

555.6

0.25

0.65

0.53

0.25

0.65

0.53

0.35

0.49

0.37

1666.7

0.84

0.93

0.81

0.84

0.93

0.81

0.66

0.79

0.46

5000.0

3.13

2.76

0.99

3.13

2.76

0.99

2.08

1.97

0.88

  1. The table reports the Combination Index (CI) value for each combination of drugs. CI < 1 indicates synergism, CI = 1 indicates additivity and CI > 1 indicates antagonism