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Table 4 Combination index values of AZD-1775 in combination with ponatinib and imatinib on BV-173 cell lines

From: Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

   

24 h

48 h

   

Ponatinb (nM)

Ponatinb (nM)

Cell line

25

50

100

25

50

100

BV-173

AZD-1775 (nM)

6.9

0.39

0.57

1.16

0.29

0.31

0.67

20.6

0.34

0.59

1.04

0.33

0.34

0.50

61.7

0.33

0.55

0.99

0.16

0.17

0.56

185.2

0.31

0.49

0.90

0.06

0.11

0.48

555.6

0.47

0.53

0.83

0.02

0.07

0.20

1666.7

0.53

0.58

0.86

0.01

0.01

0.12

5000.0

1.23

1.33

1.38

0.06

0.07

0.15

   

Imatinib (nM)

Imatinib (nM)

Cell line

250

500

1000

250

500

1000

BV-173

AZD-1775 (nM)

6.9

0.39

0.41

0.62

0.41

0.03

0.02

20.6

0.58

0.43

0.69

0.43

0.04

0.03

61.7

0.32

0.33

0.39

0.18

0.06

0.05

185.2

0.23

0.31

0.47

0.15

0.07

0.05

555.6

0.50

0.44

0.48

0.11

0.08

0.07

1666.7

0.57

0.50

0.53

0.07

0.20

0.17

5000.0

1.05

1.18

1.21

0.61

1.19

1.56

  1. The table reports the Combination Index (CI) value for each combination of drugs. CI < 1 indicates synergism, CI = 1 indicates additivity and CI > 1 indicates antagonism