Function and clinical significance of circRNAs in solid tumors

Table 3 circRNAs in breast cancer

circBase ID (alias)	Host gene	Putative function	Upregulated/downregulated	miRNA sponge	Target gene/pathway	Reference
circ-Foxo3	FOXO3	Protein scaffolding	Downregulated	–	p53	[32]
circ-Foxo3	FOXO3	miRNA sponge	Downregulated	miR-22, miR-136, miR-138, miR-149, miR-433, miR-762, miR-3614-5p, miR-3622b-5p	–	[34]
hsa_circ_0008717	ABCB10	miRNA sponge	Upregulated	miR-1271	–	[37]
hsa_circ_0001358	SEC62	miRNA sponge*	Upregulated	–	ZEB1/2	[28]
hsa_circ_000911	IFNGR2	miRNA sponge	Downregulated	miR-449a	Notch1	[36]
hsa_circ_0001982	RNF111	miRNA sponge	Upregulated	miR-143	–	[38]
hsa_circ_0005239	GFRA1	miRNA sponge	Upregulated	miR-34a	GFRA1	[39]
hsa_circ_0006528	PRELID2	miRNA sponge	Upregulated	miR-7	Raf1	[40]
circ-DENND4C	DENND4C	–	Upregulated	–	HIF1α	[41]

ISSN: 1756-8722