Emerging roles of long non-coding RNAs in tumor metabolism

Table 1 LncRNAs deregulated in cancer through targeting the signals of metabolism

LncRNA	Location	Target	Up/down	Disease
HIF1 and MYC
H19	Chr 11p15.5	HIF1A	Up	HCC [105]
SNHG12	/	C-MYC	Up	Breast cancer [113]
SARCC	/	AR	Down	RCC [115]
PCGEM1	Chr 2q32	C-MYC	Up	Prostatic cancer [111]
P53
HULC	Chr 6p24.3	P53	Up	NPC [123]
HOTAIR	Chr 12	P53	Up	Breast cancer [124]
PRAL	Chr 17p13.1	P53	Down	Lung cancer [125]
PI3K/AKT/MTOR
RP11-708H21.4	Chr 17q21	MTOR	Down	CRC [138]
UCA1	Chr 19	MTOR/STAT3	Up	CRC [63, 122]
linc00462	/	PI3/AKT	Down	HCC [139]
MALAT1	Chr 11q13	PI3/AKT	Down	Cholangiocarcinoma [177]
CASC2	Chr 10q26	PTEN	Down	CESC [7]
HULC	Chr 6p24.3	PI3/AKT	Up	Myeloid leukemia [135]
ANRIL	Chr 9q21	AKT	Up	NPC, glioma, CESC [33, 40]
AMP-activated protein kinase
LINC00473	Chr 6q27	LKB1	Up	Lung cancer [143]
NBR2	Chr 17q21	AMPK	Down	Breast cancer [34, 42]

Chr chromosome, HCC hepatocellular carcinoma, NPC nasopharyngeal carcinoma, RCC renal cell carcinoma, CESC cervical cancer

ISSN: 1756-8722