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Table 2 LncRNAs and miRNAs involved in regulating tumor metabolism

From: Emerging roles of long non-coding RNAs in tumor metabolism

Gene

Target

Signaling

Potential functions and indication

Ref.

lncRNA and glucose metabolism

 ANRIL

GLUT1 and LDHA

PI3/AKT/mTOR

Increase glucose uptake, prognosis

[33, 40]

 NBR2

GLUT1

LKB1/AMPK

Decrease glucose uptake, increases autophagy, prognosis

[34]

 CRNDE

GLUT4

PI3/AKT/mTOR

Increases glucose uptake

[30, 136]

 GCASPC

miR-17-3P

HIF1/MYC

Decrease pyruvate carboxylase, prognosis

[48]

 NRCP

STAT1

Not mentioned

Increase glycolysis, prognosis

[49]

 PVT1

HK2

miR-497/HK2 axis

Increase glucose metabolism, prognosis

[60]

 H19

let-7

HIF1/MYC

Increase insulin sensitivity, enhance glucose tolerance, prognosis

[62]

 MALAT1

 

HIF1/MYC

Increase glycolysis

[146]

microRNA and glucose metabolism

 miR-195-5p

GLUT3

LKB1/AMPK

Decrease glucose uptake

[148]

 miR-210

GPD1L

HIF1/MYC

Decrease glycolysis, prognosis

[149, 150]

 miR-223

c-MYC

HIF1/MYC

Increase glucose uptake, prognosis

[151]

 miR-143

HK2

PI3K/AKT/mTOR

Decrease glucose metabolism

[147]

 miR-21

PTEN

PI3K/AKT/mTOR

Increase glucose metabolism, prognosis

[152]

 miR-326

PKM2

LKB1/AMPK

Decrease glycolysis

[153]

 miR-451

CAB39

LKB1/AMPK

Increase glucose metabolism, prognosis

[156]

 miR-29

MCT1

P53, PI3K/AKT/mTOR

Caused insulin resistance, prognosis

[154, 155]

LncRNA and lipid metabolism

 LncHR1

SREBP-1c and FAS

PI3K/AKT/mTOR

Decrease lipid metabolism

[69]

 LNMICC

miR-190

miR-190/LNMICC/FABP5 axis

Increase fatty acid metabolism, prognosis

[71]

 SRA

Not mentioned

AKT/FOXO1 axis

Decrease adipogenesis and glucose uptake

[77]

 HULC

miR-9

miR-9/PPARγ/ACSL1 axis

Increase the deregulation of lipid metabolism

[76]

miRNA and lipid metabolism

 miR-122

CyclinB1

P53

Increase cholesterol synthesis and lipogenesis

[157]

lncRNA and glutamine metabolism

 TUG1

miR-145

Sirt3/GDH axis

Increase glutamine metabolism, prognosis

[81]

 UCA1

miR-16

PI3/AKT/mTOR

Increase glutamine metabolism

[160]

 miRNA and glutamine metabolism

 miR-23b

c-MYC

HIF1/MYC

Increase the biosynthesis of proline from glutamine

[161]