From: Emerging roles of long non-coding RNAs in tumor metabolism
Gene | Target | Signaling | Potential functions and indication | Ref. |
---|---|---|---|---|
lncRNA and glucose metabolism | ||||
 ANRIL | GLUT1 and LDHA | PI3/AKT/mTOR | Increase glucose uptake, prognosis | |
 NBR2 | GLUT1 | LKB1/AMPK | Decrease glucose uptake, increases autophagy, prognosis | [34] |
 CRNDE | GLUT4 | PI3/AKT/mTOR | Increases glucose uptake | |
 GCASPC | miR-17-3P | HIF1/MYC | Decrease pyruvate carboxylase, prognosis | [48] |
 NRCP | STAT1 | Not mentioned | Increase glycolysis, prognosis | [49] |
 PVT1 | HK2 | miR-497/HK2 axis | Increase glucose metabolism, prognosis | [60] |
 H19 | let-7 | HIF1/MYC | Increase insulin sensitivity, enhance glucose tolerance, prognosis | [62] |
 MALAT1 |  | HIF1/MYC | Increase glycolysis | [146] |
microRNA and glucose metabolism | ||||
 miR-195-5p | GLUT3 | LKB1/AMPK | Decrease glucose uptake | [148] |
 miR-210 | GPD1L | HIF1/MYC | Decrease glycolysis, prognosis | |
 miR-223 | c-MYC | HIF1/MYC | Increase glucose uptake, prognosis | [151] |
 miR-143 | HK2 | PI3K/AKT/mTOR | Decrease glucose metabolism | [147] |
 miR-21 | PTEN | PI3K/AKT/mTOR | Increase glucose metabolism, prognosis | [152] |
 miR-326 | PKM2 | LKB1/AMPK | Decrease glycolysis | [153] |
 miR-451 | CAB39 | LKB1/AMPK | Increase glucose metabolism, prognosis | [156] |
 miR-29 | MCT1 | P53, PI3K/AKT/mTOR | Caused insulin resistance, prognosis | |
LncRNA and lipid metabolism | ||||
 LncHR1 | SREBP-1c and FAS | PI3K/AKT/mTOR | Decrease lipid metabolism | [69] |
 LNMICC | miR-190 | miR-190/LNMICC/FABP5 axis | Increase fatty acid metabolism, prognosis | [71] |
 SRA | Not mentioned | AKT/FOXO1 axis | Decrease adipogenesis and glucose uptake | [77] |
 HULC | miR-9 | miR-9/PPARγ/ACSL1 axis | Increase the deregulation of lipid metabolism | [76] |
miRNA and lipid metabolism | ||||
 miR-122 | CyclinB1 | P53 | Increase cholesterol synthesis and lipogenesis | [157] |
lncRNA and glutamine metabolism | ||||
 TUG1 | miR-145 | Sirt3/GDH axis | Increase glutamine metabolism, prognosis | [81] |
 UCA1 | miR-16 | PI3/AKT/mTOR | Increase glutamine metabolism | [160] |
 miRNA and glutamine metabolism | ||||
 miR-23b | c-MYC | HIF1/MYC | Increase the biosynthesis of proline from glutamine | [161] |