Fig. 7
From: The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models
Loss of CNOT3 leads to stabilization of DNA replication and ribosome biogenesis signaling components in human T-ALL cell lines. a Workflow for the Actinomycin D experiments upon CNOT3 downregulation on T-ALL cell lines. Experiments were performed in three independent series. b Volcano plots from Jurkat and CCRF-CEM T-ALL cell lines. Those genes belonging to one of the most enriched signaling pathways are marked in color. c mRNA expression levels of CNOT3 in all conditions and mRNA expression levels of three exemplary genes that become more stable upon CNOT3 knockdown, i.e., they show an increasing difference between the knockdown and the wild-type. Experiments were performed in three independent series