Table 2 Functions of deregulated lncRNAs in EC

Sustaining growth signaling

LINC00152

Up

EGFR

[89]

Evading growth inhibitors

AK001796

Up

MDM2/p53 signaling

[93]

CASC2

Down

miR-18a-5p/PTEN axis

[99]

Uncontrolled replicative immortality

CDKN2B-AS1

Up

hTERT

[104]

BC032469

Up

hTERT

[105]

Activating invasion and metastasis

PVT1

Up

–

[106]

SNHG16

Up

miR-140-5p/ZEB1 axis

[54]

HOTAIR

Up

miR-148a/Snail2 axis

[64]

SNHG1

Up

Notch pathway

[112]

MALAT1

Up

Ezh2-Notch1 signaling, miR-200a/ZEB1, and miR-200a/ZEB2 axis

[113] [114]

CASC9

Up

–

[115]

GHET1

Up

–

[116]

TTN-AS1

Up

miR-133b/Snail1 axis, miR-133b/FSCN1 axis HuR

[117]

HOTTIP

Up

miR-30b/HOXA13 axis

[118, 119]

Promoting angiogenesis

HNF1A-AS1

Up

VEGF

[123]

Resisting apoptosis

TP73-AS1

Up

BDH2

[126]

POU6F2-AS2

Up

Ybx1

[127]

AFAP1-AS1

Up

–

[128]

LET

Down

–

[129]

Chemoradiotherapy resistance

AFAP1-AS1

Up

–

[132]

LOC285194

Up

–

[136]

BOKAS

Up

WISP1

[47]

TUSC7

down

miR-224/DESC1

[75]

Regulation of EC stem cells

MALAT1

Up

OCT4 and Nanog

[147]