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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Fig. 6

Gfi1 expression correlates with Mcl-1 expression in MM cells. Mcl-1 mRNA levels were evaluated by qPCR in MM.1S stably overexpressing Gfi1 and their respective controls EV (a). H929 cells were directly co-cultured for 4, 24, and 48 h with the normal marrow stromal cells (SAKA-T). The Gfi1 and Mcl-1 mRNA levels were analyzed by qPCR and expressed as fold change vs untreated MM cells (*p < 0.05 vs untreated control) (b). Direct correlation between Gfi1 and Mcl-1 protein levels in myeloma cells (five MM cell lines and CD138+ cells from three MM patients marked with red circles) as analyzed by WB in Fig. 1d (c)

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