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Table 3 Top 10 statistically significantly altered pathways in samples from responders to NET

From: Molecular profiling of hormone receptor-positive, HER2-negative breast cancers from patients treated with neoadjuvant endocrine therapy in the CARMINA 02 trial (UCBG-0609)

Ingenuity canonical pathways

-log (p value)

Number of genes and overlapping ratio (%)

z-score

Th1 Pathway

22.3

40 (29.6)

4.7

iCOS-iCOSL signaling in T helper cells

17.0

33 (26.8)

4.3

CD28 signaling in T helper cells

16.9

34 (25.8)

3.8

PKCθ signaling in T lymphocytes

14.2

31 (23.3)

4.4

Role of NFAT in regulation of the immune response

12.9

34 (18.8)

5.0

B Cell receptor signaling

7.9

28 (14.7)

3.5

Calcium-induced T lymphocyte apoptosis

7.9

16 (24.2)

4.0

Tec kinase signaling

7.8

26 (15.3)

3.7

PI3K signaling in B lymphocytes

7.5

22 (16.9)

4.1

Neuroinflammation signaling pathway

6.7

35 (11.3)

2.7

  1. Only top canonical pathways with predictive z-score ≥ 2 are presented, together with a p value. The overlapping ratio indicates the ratio of genes from the dataset that map to the pathway divided by the total number of genes that map to the same pathway