Fig. 2

Measures of POEMS syndrome burden and clinical responses to infusions of anti-BCMA CAR-T cells. a The trend in IgG and M spike concentrations on the course of the all treatment, with PDN combined HGG, with LEN combined DXM and anti-BCMA CAR-T cells infusion. b Serum soluble BCMA and VEGF of the patients was measured by ELISA before, and after anti-BCMA CAR-T cells infusion, they both decreased post-treatment obviously. c Twenty-four hours after anti-BCMA CAR-T cells infusion, the patient became febrile. She was febrile for 7 days. The plot shows the maximum temperature for each day. Serum levels of cytokines were measured at the indicated time points. Levels of IL-6 and ferritin elevated markedly on day 3 and then dropped quickly. d Changes in the white blood cell and platelet count, hemoglobin level. e Anti-BCMA CAR-T cells engraftment, measured by means of flow cytometry as the number of cells per cubic millimeter, and the corresponding B cell frequencies, measured as the number of cells per cubic millimeter (in peripheral blood)