Fig. 4

Measures of multiple myeloma burden and clinical responses to infusions of anti-BCMA CAR-T cells. a Before protocol treatment, the patient had a hypercellular bone marrow (hematoxylin and eosin). Bone marrow cells were 25% plasma cells as shown by CD138 staining. BCMA expression was obvious (original magnification, × 400). b Three months after CAR-T cell infusion, bone marrow plasma cells were completely absent as shown by the negative CD138 and BCMA staining (original magnification, × 400). c The trend in the patient’s serum M spike, free light chains, and BCMA concentrations after anti-BCMA CAR-T cells infusion, all of which decreased obviously. In the eighth month, these indicators began to rise. d Anti-BCMA CAR-T cells engraftment, measured by means of flow cytometry as the number of cells per cubic millimeter, and the corresponding B cell frequencies, measured as the number of cells per cubic millimeter (in peripheral blood). e 72 h after CAR-BCMA infusion, the patient became febrile. She was febrile for 7 days. The plot shows the maximum temperature for each day. The levels of IL-6 and ferritin was elevated