Table 2 LncRNAs involved in regulating cell proliferation

AML

CASC15

MTS assay

CASC15 expression may limit cell proliferation by regulation SOX4 expression

siRNA

[93]

AML

CCAT1

CKK-8 assay

Promotes cell proliferation by sequestering tumor suppressive miR155

shRNA

[89]

AML

MEG3

MTT assay

Suppresses cell proliferation through inducing G0/G1 cell cycle arrest

siRNA

[91]

AML

NEAT1

CCK-8 assay

Modulates cell proliferation by regulating miR-23a-3p/SMC1A

pcDNA3.1-NEAT1 (overexpression of NEAT1)

[90]

AML

TUG1

CKK-8 assay

Increases cell proliferation through targeting AURKA

Lentiviral vector-mediated gene manipulation

[92]

AML

UCA1

Trypan Blue exclusion assay

Sustains cell proliferation by repressing p27^kip1 expression

shRNA

[87]

ALL

LINC-PINT

MTS assay

Overexpressed linc-PINT decreases cell proliferation through apoptosis activation and cell cycle arrest at G2/M phase

Overexpression of linc-PINT by linc-PINT-pCDNA3

[94]

ALL

NALT

CKK-8 assay

Upexpressed NALT promotes cell proliferation through interacting with NOTCH signaling pathway

shRNA

[86]

APL

PVT1

CKK-8 assay

Promotes cell proliferation by MYC

siRNA

[95]

CML

HULC

MTT assay

Promotes cell proliferation by regulating PI3K/AKT signaling pathway

shRNA

[97]

CML

MEG3

MTT assay

Overexpressed MEG3 inhibits cell proliferation by sponging miR-21

pLVX-hMEG3-ZsGreen-Puro lentiviral overexpression vector

[96]

CML

MEG3

CCK-8 assay

Overexpressed MEG3 inhibits cell proliferation by inhibiting miR-184

siRNA

[188]

CML

PLIN2

MTT assay

Overexpressed PLIN2 promotes cell proliferation through activating GSK-3β and β-catenin

shRNA

[98]

CLL

BM742401

MTT assay

Overexpressed BM742401 inhibits cell proliferation through caspase-9 dependent intrinsic pathway

ASO

[88]