Table 3 LncRNAs involved in cell cycle regulation

LncRNA-HEIH

Suppresses p16. p21, p27, and p57 transcription with PRC2 (G0/G1)

[109]

MEG3

Suppresses cyclin D1 and induction of cell cycle arrest in G0/G1 phase

[110]

ANRIL

Suppresses CDK inhibitors encoded by the INK4 locus

Suppresses transcription of p14, p15, and p16 in DNA damage response (G1)

[189, 190]

HOTAIR

Regulates expression of cell cycle regulators such as cyclin D1, cyclin E, CDK2, CDK4, E2F1 (G1/S)

[107, 108]

HOXA11-AS

Suppresses CDK inhibitors p16, p21, p27, and Rb protein (G1/S)

[40]

NcRNA_CCND1

Suppresses transcription of cyclin D1 (G1/S)

[111]

PANDA

Suppresses CDK inhibitor p21 produced from CDKN1A locus

Suppresses transcription of p18 (G1/S)

[39, 112]

MALAT1

Regulates cell cycle via interaction with hnRNP C

Promotes cell-cycle regulators such as cyclin A2 and B1 (G1 and G2/M)

[105, 106, 191]