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Table 4 Differentiation-associated lncRNAs in hematopoiesis

From: Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies

lncRNA Observations in lineage differentiation References
HOTAIRM1 Expression shows myeloid lineage specificity and increases during granulocytic differentiation [114, 115]
LINC00173 Specifically expressed in mature granulocytes; controls differentiation of myeloid progenitor cells towards granulocytes [24]
NEAT1 Highly expressed in APL cells; NEAT1 depletion stopped ATRA-induced granulocytic differentiation [116]
LncRNAp53int1 Expressed in undifferentiated human myeloid leukemia cells and greatly reduced during differentiation towards monocytes and macrophages [117]
Lnc-MC Increased expression promotes differentiation from monocytes to macrophage through sequestering miR-199a-5p [118]
Lnc-DC Exclusively expressed in dendritic cells (DCs); knockdown study showed its involvement in DC differentiation [119]
EGO Highly expressed in mature eosinophils; knockdown of EGO influenced the expression of regulators in eosinophilopoiesis [120]
PU.1 AS Negatively regulates the mRNA translation of the master hematopoietic transcription factor PU.1 [121]