Table 4 Differentiation-associated lncRNAs in hematopoiesis

HOTAIRM1

Expression shows myeloid lineage specificity and increases during granulocytic differentiation

[114, 115]

LINC00173

Specifically expressed in mature granulocytes; controls differentiation of myeloid progenitor cells towards granulocytes

[24]

NEAT1

Highly expressed in APL cells; NEAT1 depletion stopped ATRA-induced granulocytic differentiation

[116]

Expressed in undifferentiated human myeloid leukemia cells and greatly reduced during differentiation towards monocytes and macrophages

[117]

Lnc-MC

Increased expression promotes differentiation from monocytes to macrophage through sequestering miR-199a-5p

[118]

Lnc-DC

Exclusively expressed in dendritic cells (DCs); knockdown study showed its involvement in DC differentiation

[119]

EGO

Highly expressed in mature eosinophils; knockdown of EGO influenced the expression of regulators in eosinophilopoiesis

[120]

PU.1 AS

Negatively regulates the mRNA translation of the master hematopoietic transcription factor PU.1

[121]