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Table 6 LncRNAs associated with angiogenesis in human cancers

From: Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies

Cancer type

LncRNA

Functional involvement of lncRNAs in angiogenesis

References

Disease phenotype

Mechanism of action

Gastric cancer

OR3A4

Promotes cell proliferation, migration, invasion, tumorigenesis, angiogenesis

Increases VEGF-C and MMP9 expression

[143]

MALAT1

Promotes tumorigenicity and metastasis

Regulation of VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways

[144]

PVT1

Induce angiogenesis within tumors

Mediates angiogenesis via evoking the STAT3/VEGFA signaling axis

[145]

CASC2

Inhibits cell invasion and angiogenesis

–

[146]

Glioblastoma

TUG1

Promotes cell proliferation, migration and angiogenesis

Promotes blood-tumor barrier permeability and angiogenesis

Increases VEGFA expression through downregulation of miRNA-299

[63]

XIST

Inhibition of FOXC1 and ZO-2 by upregulating miR-137

[147]

Glioma

HULC

Promotes cell proliferation and angiogenesis

Upregulation of ESM-1 through PI3K/Akt/mTOR signaling pathway

[148]

H19

Promotes angiogenesis

Increases the VASH2 expression through overexpressing miRNA-29a

[149]

Hepatocellular carcinoma

HULC

Promotes cell proliferation and angiogenesis

Upregulation of SPHK1through miRNA-107/E2F1/SPHK1 signaling pathway

[150]

MVIH

Promotes cell growth and metastasis

Inhibition of PGK1 secretion

[151]

Hepatoblastoma

TUG1

Promotes cell proliferation, migration and angiogenesis

Increases VEGFA expression by miR-34a-5p downregulation

[152]

CRNDE

Promotes tumor growth and tumor angiogenesis

Regulates mTOR signaling pathways

[153]

Nasopharyngeal carcinoma

HOTAIR

Promotes cell growth and angiogenesis

Upregulation of VEGFA and Ang2 by GRP78

[56]

Neuroblastoma

MALAT1

Promotes angiogenesis

Upregulation of FGF2 expression

[154]

Diabetes

MIAT

Promotes ocular angiogenesis

Upregulation of VEGF by miRNA-150-5p

[155]

Pituitary adenomas

MEG3

Suppresses tumor cell proliferation and angiogenesis

Suppression of VEGF signaling pathway

[156]