Skip to main content

Advertisement

Table 6 LncRNAs associated with angiogenesis in human cancers

From: Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies

Cancer type LncRNA Functional involvement of lncRNAs in angiogenesis References
Disease phenotype Mechanism of action
Gastric cancer OR3A4 Promotes cell proliferation, migration, invasion, tumorigenesis, angiogenesis Increases VEGF-C and MMP9 expression [143]
MALAT1 Promotes tumorigenicity and metastasis Regulation of VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways [144]
PVT1 Induce angiogenesis within tumors Mediates angiogenesis via evoking the STAT3/VEGFA signaling axis [145]
CASC2 Inhibits cell invasion and angiogenesis [146]
Glioblastoma TUG1 Promotes cell proliferation, migration and angiogenesis Promotes blood-tumor barrier permeability and angiogenesis Increases VEGFA expression through downregulation of miRNA-299 [63]
XIST Inhibition of FOXC1 and ZO-2 by upregulating miR-137 [147]
Glioma HULC Promotes cell proliferation and angiogenesis Upregulation of ESM-1 through PI3K/Akt/mTOR signaling pathway [148]
H19 Promotes angiogenesis Increases the VASH2 expression through overexpressing miRNA-29a [149]
Hepatocellular carcinoma HULC Promotes cell proliferation and angiogenesis Upregulation of SPHK1through miRNA-107/E2F1/SPHK1 signaling pathway [150]
MVIH Promotes cell growth and metastasis Inhibition of PGK1 secretion [151]
Hepatoblastoma TUG1 Promotes cell proliferation, migration and angiogenesis Increases VEGFA expression by miR-34a-5p downregulation [152]
CRNDE Promotes tumor growth and tumor angiogenesis Regulates mTOR signaling pathways [153]
Nasopharyngeal carcinoma HOTAIR Promotes cell growth and angiogenesis Upregulation of VEGFA and Ang2 by GRP78 [56]
Neuroblastoma MALAT1 Promotes angiogenesis Upregulation of FGF2 expression [154]
Diabetes MIAT Promotes ocular angiogenesis Upregulation of VEGF by miRNA-150-5p [155]
Pituitary adenomas MEG3 Suppresses tumor cell proliferation and angiogenesis Suppression of VEGF signaling pathway [156]