Cancer type | LncRNA | Functional involvement of lncRNAs in angiogenesis | References | |
---|---|---|---|---|
Disease phenotype | Mechanism of action | |||
Gastric cancer | OR3A4 | Promotes cell proliferation, migration, invasion, tumorigenesis, angiogenesis | Increases VEGF-C and MMP9 expression | [143] |
MALAT1 | Promotes tumorigenicity and metastasis | Regulation of VE-cadherin/β-catenin complex and ERK/MMP and FAK/paxillin signaling pathways | [144] | |
PVT1 | Induce angiogenesis within tumors | Mediates angiogenesis via evoking the STAT3/VEGFA signaling axis | [145] | |
CASC2 | Inhibits cell invasion and angiogenesis | – | [146] | |
Glioblastoma | TUG1 | Promotes cell proliferation, migration and angiogenesis Promotes blood-tumor barrier permeability and angiogenesis | Increases VEGFA expression through downregulation of miRNA-299 | [63] |
XIST | Inhibition of FOXC1 and ZO-2 by upregulating miR-137 | [147] | ||
Glioma | HULC | Promotes cell proliferation and angiogenesis | Upregulation of ESM-1 through PI3K/Akt/mTOR signaling pathway | [148] |
H19 | Promotes angiogenesis | Increases the VASH2 expression through overexpressing miRNA-29a | [149] | |
Hepatocellular carcinoma | HULC | Promotes cell proliferation and angiogenesis | Upregulation of SPHK1through miRNA-107/E2F1/SPHK1 signaling pathway | [150] |
MVIH | Promotes cell growth and metastasis | Inhibition of PGK1 secretion | [151] | |
Hepatoblastoma | TUG1 | Promotes cell proliferation, migration and angiogenesis | Increases VEGFA expression by miR-34a-5p downregulation | [152] |
CRNDE | Promotes tumor growth and tumor angiogenesis | Regulates mTOR signaling pathways | [153] | |
Nasopharyngeal carcinoma | HOTAIR | Promotes cell growth and angiogenesis | Upregulation of VEGFA and Ang2 by GRP78 | [56] |
Neuroblastoma | MALAT1 | Promotes angiogenesis | Upregulation of FGF2 expression | [154] |
Diabetes | MIAT | Promotes ocular angiogenesis | Upregulation of VEGF by miRNA-150-5p | [155] |
Pituitary adenomas | MEG3 | Suppresses tumor cell proliferation and angiogenesis | Suppression of VEGF signaling pathway | [156] |