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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer

Fig. 3

PIK3CA E542K and E545K mutations enhance the expression and nuclear accumulation of β-catenin. a The expression of AKT/GSK3 β/β-catenin in SiHa and MS751 cells with wild-type and mutant PIK3CA. b The effect of knocking down β-catenin on proliferation in SiHa and MS751 cells with wild-type and mutant PIK3CA. c The effect of knocking down β-catenin on glucose uptake and lactate production in SiHa and MS751 cells with wild-type and mutant PIK3CA (**P < 0.01). d The location of β-catenin was analyzed by immunofluorescence staining in SiHa cells. e The expression of β-catenin at nucleus in SiHa cells with wild-type and mutant PIK3CA by western blotting. f The representative imaging of β-catenin in membrane, cytoplasm, and nucleus by IHC in 60 patients with cervical cancer. g The corresponding proportion of β-catenin in membrane, cytoplasm, and nucleus in tissues of patients with wild-type and E542K, E545K mutant PIK3CA

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