Fig. 4

SIRT3 is a negative effector of β-catenin in regulating glucose metabolism. a Relative mRNA expression of SIRT3, GLUT4, and LDHB in SiHa cells with PIK3CA E542K and E545K mutations. b The expression of SIRT3 in SiHa and MS751 cells with wild-type and mutant PIK3CA. c Effect of knocking down β-catenin on the expression of SIRT3 and key glycolytic enzymes. d Relative SIRT3 promotor activity in SiHa cells with downregulation of β-catenin (**P < 0.01). e Knocking down SIRT3 rescued the effect of shβ-catenin on glucose uptake, lactate production (**P < 0.01). f Knocking down SIRT3 rescued the effect of shβ-catenin on key glycolytic enzymes