Table 1 PIK3CA mutation distribution in cervical cancer, breast cancer, and endometrial carcinoma
Cervical cancer (n = 990) | Breast cancer (n = 817) | Endometrial carcinoma (n = 248) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Amino acid change | No. of cases | Frequency of variants (%) | Amino acid change | No. of cases | Frequency of variants (%) | Amino acid change | No. of cases | Frequency of variants (%) | |
Exon 9 E542 | E542K | 43 | 4.3 | E542K | 30 | 3.7 | E542K | 9 | 3.6 |
E542G | 2 | 0.2 | E542A | 2 | 0.8 | ||||
E542Q | 1 | 0.4 | |||||||
E542V | 1 | 0.4 | |||||||
Total | 43 | 4.3 | Total | 32 | 3.9 | Total | 13 | 5.2 | |
Exon 9 E545 | E545K | 84 | 8.5 | E545K | 54 | 6.6 | E545K | 10 | 4.0 |
E545A | 1 | 0.1 | E542A | 2 | 0.2 | E545D | 2 | 0.8 | |
E545D | 1 | 0.1 | E545R | 1 | 0.1 | E545A | 1 | 0.4 | |
E545Q | 1 | 0.1 | E545G | 1 | 0.4 | ||||
Total | 87 | 8.8 | Total | 57 | 7.0 | Total | 14 | 5.6 | |
Exon 20 H1047 | H1047R | 5 | 0.5 | H1047R | 116 | 14.2 | H1047R | 12 | 4.8 |
H1047L | 1 | 0.1 | H1047L | 11 | 1.3 | H1047L | 6 | 2.4 | |
H1047Y | 1 | 0.1 | H1047Y | 1 | 0.4 | ||||
H1047Q | 1 | 0.4 | |||||||
Total | 6 | 0.6 | Total | 128 | 15.7 | Total | 20 | 8.1 | |