Fig. 2
From: Universal CARs, universal T cells, and universal CAR T cells
The structure of BBIR CAR. In the BBIR CAR, avidin serves as the extracellular ligand binding domain and is linked to the transmembrane and intracellular signaling domains. The biotinylated antigen-specific molecules can be full-length antibodies, scFvs, or other tumor-specific ligands. Through the binding of biotin to avidin, any extracellular signal linked to the biotin can activate the T cells. Therefore, the BBIR CAR remains constant and can serve as a universal CAR. (adapted from Urbanska, K, et al.; Cancer Res. 2012; 72(7); 1844–1852)