Fig. 7

Significant associations between dysregulated pathways and drug responses. The number of hits in each pathway was plotted against the drug z-score. Robust linear regression is displayed; regression line was drawn according to coefficients obtained after 5000 bootstrapped replicates. Only significant associations of tested drugs with the pathways of interest are displayed. Drugs responses were detailed in Methods, as durations and assessment of response differ according to drugs pharmacodynamical specificities. a Drug responses associated with dysregulation in the p53 pathway. b Drug responses associated with dysregulation in the DNA damage pathway. c Drug responses associated with dysregulation in the MAPK pathway. d RITA sensitivity correlated with the helicase hit scores in TP53^wt HMCLs. TP53^wt and TP53^Abn HMCLs are represented by black and red dots, respectively. The lethal-dose-50 of RITA was determined as previously described [13]. Asterisk indicates not statistically significant