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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD

Fig. 6

MSCs-exo was uptaken by T cells and regulated cell differentiation. a Representative images of exosome uptake by isolated CD3 T cells. b PBMCs were isolated from healthy donors and stimulated with PHA and Fib-exo or MSCs-exo (10 μg/ml or 50 μg/ml). MSCs-exo with both doses upregulated the percentage of CD25 + Foxp3 + CD4+ Treg cells. The higher-dose MSCs-exo group with 50 μg/ml presented more Treg cells. c When cultured under Th17 culture conditions, MSCs-exo markedly suppressed the differentiation of Th17 cells. Data are expressed as the mean ± SEM. **P < .01 and ***P < .001; ns not significant

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