Skip to main content

Table 3 Multivariate analysis of risk stratification of patients based on the CAFs FGF-2 and VEGF

From: Prognostic or predictive value of circulating cytokines and angiogenic factors for initial treatment of multiple myeloma in the GIMEMA MM0305 randomized controlled trial

Variable PFS OS
Risk group Risk group
Low Intermediate High Low Intermediate High
HR
(95 CI)
p HR
(95 CI)
p HR
(95 CI)
p HR
(95 CI)
p HR
(95 CI)
p HR
(95 CI)
p
Sex 0.82
(0.59–1.18)
0.3698 0.74
(0.59–1.11)
0.9645 0.86
(0.62–1.08)
0.3438 0.80
(0.57–1.05)
0.3698 0.96
(0.68–1.33)
0.6905 0.86
(0.59–1.16)
0.5713
Age (< 65 years) 0.96
(0.69–1.35)
0.7647 0.87
(0.55–1.20)
0.2027 0.73
(0.59–0.98)
0.0455 0.97
(0.71–1.32)
0.7647 0.61
(0.44–0.85)
0.0047 0.60
(0.38–0.89)
0.0391
Isotype 0.91
(0.56–1.32)
0.2957 0.91
(0.64–1.31)
0.6951 0.96
(0.68–1.33)
0.6419 0.82
(0.51–1.21)
0.2957 0.83
(0.57–1.15)
0.3627 0.98
(0.81–1.22)
0.8179
D&S stage 0.84
(0.60–1.16)
0.3218 0.82
(0.57–1.22)
0.3505 0.64
(0.49–0.89)
0.0169 0.83
(0.59–1.11)
0.3218 0.98
(0.67–1.44)
0.7874 0.74
(0.59–1.12)
0.0593
ISS stage 0.94
(0.66–1.29)
0.8163 0.91
(0.55–1.24)
0.2107 0.84
(0.58–1.28)
0.0619 0.79
(0.61–1.07)
0.1087 0.97
(0.66–1.34)
0.5221 0.87
(0.62–1.27)
0.0665
Cytogenetic risk 0.93
(0.64–1.28)
0.6358 0.87
(0.56–1.22)
0.3451 0.91
(0.55–1.33)
0.6670 0.86
(0.71–1.32)
0.2399 0.89
(0.69–1.41)
0.6133 0.92
(0.71–1.37)
0.6112
Renal failure 0.94
(0.61–1.25)
0.5866 0.92
(0.59–1.44)
0.6957 0.87
(0.60–1.21)
0.2410 0.92
(0.66–1.41)
0.5866 0.94
(0.71–1.35)
0.6108 0.97
(0.74–1.25)
0.8902
Induction therapy 0.84
(0.61–1.28)
0.3520 0.93
(0.66–1.34)
0.6838 0.88
(0.58–1.18)
0.3356 0.84
(0.57–1.19)
0.3520 0.93
(0.70–1.32)
0.6075 0.89
(0.66–1.28)
0.6015
Best response to induction therapy (≥ VGPR) 0.76
(0.59–1.18)
0.0984 0.68
(0.48–0.96)
0.0342 0.71
(0.55–1.08)
0.0533 0.74
(0.59–1.09)
0.0984 0.95
(0.69–1.31)
0.5031 0.88
(0.61–1.29)
0.0583
Maintenance 0.70
(0.44–0.89)
0.0210 0.54
(0.38–0.80)
0.0008 0.71
(0.56–0.92)
0.0249 0.70
(0.48–0.88)
0.0210 0.74
(0.57–1.01)
0.0330 0.52
(0.36–0.75)
0.0003
  1. p values less than 0.05 was considered significant