Fig. 4

Heatmap of differentially expressed genes between the IB136 and resIB136-derived xenografts. a Heatmap based on mean, normalized expression of general differentially expressed genes. b Heatmap based on mean, normalized expression of stem cell signaling components. The red and green colors denote high and low intensities, respectively. c Immunohistochemical staining images of tumor samples treated with anti-SOX2 and anti-ALDH1 antibodies (objective magnification, × 10). Percentages correspond to positively stained cells estimated by a pathologist. Endothelial cells (positive control) are indicated by black arrows