Fig. 3

Waterfall plot of changes in the target lesions with a representative case of clinical response. a Chiauranib dose cohorts are shown in parentheses as 1 = 10 mg, 2 = 20 mg, 3 = 35 mg, 4 = 50 mg, and 5 = 65 mg. Open bars represent patients who had progressive disease, and the filled bars represent patients who achieved stable disease as their best responses. Not shown, n = 3, due to unavailable tumor measurements. Coronal chest CT at baseline (b) and after 4 weeks chiauranib treatment (c) from a 59-year-old woman with poorly differentiated adenocarcinoma of the lung, who has been received surgery, adjuvant chemotherapy, chemo-radiation, and two salvage chemotherapies