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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells

Fig. 5

Transcriptional factor six2 promotes the stemness of breast cancer cells in vitro. a Venn diagram showing the overlap of genes in MCF-7-Z1-UTR, MCF-7-Z2P-UTR, and MCF-7-six2 cells. b Pearson correlation of altered genes in MCF-7-Z1-UTR, MCF-7-Z2P-UTR, and MCF-7-six2 cells. c mRNA levels of six2 were examined in breast cancer and normal adjacent tissues via online deposited data (n = 1207, the error bars denote the ± SDs, P < 0.0001). d Six2 expression was evaluated in a tissue microarray including 30 breast cancer tissues and 30 normal adjacent tissues via immunohistochemistry analysis. e Heat map showing the mean expression values of genes related to stem cell pluripotency in MCF-7 cells with CYP4Z2P-3′UTR or CYP4Z1-3′UTR or six2 overexpression (fold change > 2 relative to MCF-7 cells, P < 0.05). f, g Enrichment of a stem cell signature according to a GSEA of genes regulated in MCF-7-six2 cells

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Journal of Hematology & Oncology

ISSN: 1756-8722

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