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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation

Fig. 2

Selection techniques for the isolation of virus-specific T cells. Generation of virus-specific T cells by in vitro stimulation and expansion or direct selection. Firstly, cells are stimulated specifically via viral peptide/protein/lysate or antigen-presenting cells. Secondly, cells can either be used for in vitro expansion or isolation and direct infusion into the patient. Large amounts of virus-specific T cells can be obtained from a small starting volume of blood by in vitro stimulation and expansion. T -cell products from direct selection of virus-specific cells via peptide HLA multimers, cytokine-capture technique, or activation markers are obtained in small amounts and are infused into the patient where they expand under physiological conditions

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