Table 3 Clinical evidence for adoptive transfer of AdV-specific T cells

Geyeregger et al. (2014) [53]

Allogeneic AdV-specific polyclonal CD8⁺ and CD4⁺ T cells

1/2 complete response 1/2 partial response

10⁴ CD3⁺ cells/kg

Withers et al. (2017 and 2018) [55, 59]

AdV-specific third-party CD8+ and CD4+ T cells phase I

1/1 responded

1 infusion of 1.37–5 × 10⁷ cells/m²

Uhlin et al. (2012) [60]

Allogeneic AdV-specific CD8⁺ T cells using MHC-I-pentamers

5/6 responders

3.1 × 10⁴ and 1.7 × 10⁴ cells/kg

Feuchtinger et al. (2006) [52]

AdV-specific polyclonal CD8⁺ and CD4⁺ T cells

5/6 responders

1.2–50 × 10³ cells/kg

Qasim et al. (2013) [67]

AdV-specific polyclonal CD8⁺ and CD4⁺ T cells

3/5 responders

10⁴ cells/kg

Feucht et al. (2015) [30]

AdV-specific polyclonal CD8⁺ and CD4⁺ T cells

21/30 responders

0.3–24 × 10³ CD3⁺ cells/kg

Kàllay et al. (2018) [43]

AdV-specific polyclonal CD8⁺ and CD4⁺ T cells

1/1 responder

2.7 × 10⁴ cells/kg