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Table 3 Clinical evidence for adoptive transfer of AdV-specific T cells

From: Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation

Reference Method No. of patients Results Dose
In vitro stimulation and expansion
Geyeregger et al. (2014) [53] Allogeneic AdV-specific polyclonal CD8+ and CD4+ T cells 2 1/2 complete response 1/2 partial response 104 CD3+ cells/kg
Withers et al. (2017 and 2018) [55, 59] AdV-specific third-party CD8+ and CD4+ T cells phase I 1 1/1 responded 1 infusion of 1.37–5 × 107 cells/m2
Direct isolation via peptide-HLA multimers
Uhlin et al. (2012) [60] Allogeneic AdV-specific CD8+ T cells using MHC-I-pentamers 8 5/6 responders 3.1 × 104 and 1.7 × 104 cells/kg
Direct isolation via cytokine-capture technique
Feuchtinger et al. (2006) [52] AdV-specific polyclonal CD8+ and CD4+ T cells 9 5/6 responders 1.2–50 × 103 cells/kg
Qasim et al. (2013) [67] AdV-specific polyclonal CD8+ and CD4+ T cells 5 3/5 responders 104 cells/kg
Feucht et al. (2015) [30] AdV-specific polyclonal CD8+ and CD4+ T cells 30 21/30 responders 0.3–24 × 103 CD3+ cells/kg
Kàllay et al. (2018) [43] AdV-specific polyclonal CD8+ and CD4+ T cells 1 1/1 responder 2.7 × 104 cells/kg