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Table 2 Inotuzumab ozogamicin for relapsed or refractory B cell acute lymphoblastic leukemia

From: Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia

 

Day 1

Day 8

Day 15

Induction*

 Cycle 1

0.8 mg/m2

0.5 mg/m2

0.5 mg/m2

 Cycle length

21 days

Consolidation#

 Dose

0.5 mg/m2

0.5 mg/m2

0.5 mg/m2

 Cycle length

28 days

  1. *This may be repeated if patients do not achieve CR/CRi after cycle 1, though cycle length after cycle 1 should be 28 days
  2. #For patients planning to receive an allogeneic transplant, treatment with inotuzumab ozogamicin should be limited to 2 cycles of induction or the fewest number of cycles required to achieve a CR/CRi (if CR/CRi not achieved after 2 cycles)