Skip to main content

Table 1 Lymphodepletion (LD) regimen in the universal CAR T trials PALL and CALM

From: Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia

LD regimen (FC or FCA)

Doses in PALL

Doses in CALM

Fludarabine (F)

150 mg/m2

90 mg/m2

Cyclophosphamide (C)

120 mg/kg

1500 mg/m2

Alemtuzumab (A)

1 mg/kg (capped at 40 mg)

1 mg/kg or 40 mg

  1. The regimen and chemotherapy doses were based on data presented at 2018 ASH Annual meeting by Benjamin et al. [115]
  2. PALL UCART19 trial in pediatric patients, NCT 02808442; CALM UCART19 trial in adult patients, NCT 02746952