Fig. 1

miR-195-5p was downregulated in CRC tumor samples with upregulation of NOTCH2. a miR-195-5p expressions in 6 pair CRC samples. b miR-195-5p is significantly decreased in primary human CRC tissues compared with ANT. Mean ± SD is shown. Statistical analysis was conducted using Student’s t test. c The levels NOTCH2 protein in 6 pairs of CRC samples. d NOTCH2 protein is significantly increased in primary human CRC tissues compared with ANT. Mean ± SD is shown. Statistical analysis was conducted using Student’s t test. e Scatter plots showing the negative correlation between miR-195-5p and NOTCH2 protein levels