Fig. 7

Summary of study. Early myeloid-derived suppressor cells (HLA-DR^−/lowCD33⁺CD16⁻) expanded by granulocyte colony-stimulating factor derived from G-CSF-mobilized donor PBSCs. This MDSC population suppressed T cell proliferation in vitro and in humanized mouse model, potentially by TGF-β-dependent manner, and promoted Treg generation, which also prevents acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post-allo-HSCT