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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

Fig. 6

Low levels of RNF128 coupled with overexpression of CD44 and CTTN are associated with poorer prognosis in melanoma patients. a RNF128, CD44, and CTTN mRNA levels in 30 melanoma tissues (left), and the correlation analysis between RNF128 and CD44 or CTTN at the mRNA levels was performed using the Spearman correlation coefficient (right). b Representative bands of RNF128 protein levels in 30 melanoma tissues are shown (left), and the correlation analysis between RNF128 and CD44 or CTTN at the protein levels was performed using the Spearman correlation coefficient (right). c Representative images of TMA stained with H&E and IHC for the RNF128, CD44, and CTTN antibodies. d, e Correlation analysis of integrated RNF128 density levels with integrated CD44 (d) or CTTN (e) density levels using the Spearman correlation coefficient. f Kaplan-Meier analyses showing the relationship between RNF128 expression and overall survival (upper) or recurrence (lower), p values were calculated by the log-rank test. g Kaplan-Meier analyses showing the relationships between the differential expression of RNF128, CD44, CTTN, and overall survival or recurrence using the log-rank test. *p < 0.05, ***p < 0.001. T, tumor; P, peritumor

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