Fig. 2
From: Molecular pathogenic pathways in extranodal NK/T cell lymphoma
Targeted therapies with greatest clinical significance based on biological knowledge in ENKTL. Extranodal NK/T cell lymphoma, nasal type (ENKTL) frequently show oncogenic activation of JAK/STAT and NF-κB pathways that promote proliferation and survival of the lymphoma cells. These signaling pathways can be targeted by a variety of small molecule inhibitors. Antibody drugs targeting a number of overexpressed membrane proteins, such as PD-L1, CD38, and vascular endothelial growth factor receptor (VEGFR), are being evaluated in clinical trials