Fig. 1

P53 regulate ferroptosis. P53^3KR cannot elicit apoptosis activity, it retains the ability to promote ferroptosis. GLS2 and SAT1 contribute, at least in part, to P53^3KR-mediated ferroptosis. P53^3KR completely retains the ability to regulate the expression of SLC7A11. Interestingly, WTP53 inhibits ferroptosis via blocking the DPP4 activity. And WTP53 can delay ferroptosis by promoting the expression of P53 transcriptional target CDKN1A. However, P53^3KR is unable to induce P21. Other P53 mutants, P53^4KR, P53^P47S, and TP53^KO, cannot induce ferroptosis and weaken the blocking of cell growth