Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Mou, Yanhua; Wang, Jun; Wu, Jinchun; He, Dan; Zhang, Chunfang; Duan, Chaojun; Li, Bin

doi:10.1186/s13045-019-0720-y

Journal of Hematology & Oncology

Table 2 Non-coding RNA associated with ferroptosis

From: Ferroptosis, a new form of cell death: opportunities and challenges in cancer

ncRNA	Target	Cell lines	Mechanisms of action	Function	Ref
P53RRA	p53	A549, H522, SPCA1	Leads to higher retention of p53 in the nucleus, increases lipid ROS and iron concentrations	Promote	[24]
miR-9	GOT1	A375, G-361	Suppressed GOT1, which ultimately converts Glu to a-KG	Suppress	[25]
miR-137	SLC1A5	A375, G-361	Suppressed SLC1A5, resulting in decreased Gln uptake and malondialdehyde (MDA) accumulation	Suppress	[26]
miR-375	SLC7A11	MCF7	Effectively suppress the expression of SLC7A11	Promote	[27]
miR-27a		EJ/T24, RT112			[28]
miR-26b		CAL-27, Tca8113VC			[29]
As-SLC7A11		A433, OVCA429, TOV112D			[30]
miR-7	Nrf2	SH-SY5Y	Activates Nrf2 pathway by targeting Keap1 expression	Suppress	[31]
miR-200a		MCF-10A, MDA-MB-231	Activates Nrf2 pathway by targeting Keap1 expression		[32]
miR-101		HUVECs	Activate Nrf2 signaling by directly targeting Cul3		[34]
miR-455		hFOB1.19	Activate Nrf2 signaling by directly targeting Cul3		[35]
miR-153		SH-SY5Y	Directly target Nrf2 and downregulate expression of Nrf2	Promote	[36]
miR-142-5p
miR-27a
miR-144		K562, SH-SY5Y	Reduced levels of Nrf2, decreased GSH		[37]
miR-93		MCF-10A, T47D	Decreased protein expression of Nrf2 and Nrf2- regulated genes		[38]
miR-34a		NRK-52E, HK-2	Decreased levels of Sirt1, which is required for the activation of Nrf2 system		[39]
miR-28		MCF-7	Inhibits Nrf2 expression through a Keap1- independent manner		[33]
miR-365-1		BEAS-2B, A549, 3 T3-L1	Decreased protein expression of Nrf2 genes		[40]
miR-193b
miR-29-b1
miR-20a	FPN	Huh7, NSCLC	Represses FPN expression by directly targeting the FPN 39UTR	Promote	[41]
miR-485-3p	FPN	HepG2, K562		Promote	[42]
miR-210	TFR	MCF7	Decreases the uptake of transferrin by inhibiting the expression of TFR	Suppress	[43]
miR-152	TFR1	SK-HEP1, HepG2	Effectively inhibit the expression level of TFR1		[44]
miR-200b	FTH	MDA-MB-231	Effectively inhibit the expression levels of FTH		[45]
miR-Let-7d	DMT1-IRE	K562, HEL	Reduces iron accumulation and simultaneously regulates the expression level of DMT1-IRE		[46]
miR-3595	ACSL4	HSC-T6	Inhibits the expression of mRNA and protein in ACSL4	Suppress	[47]
miR-205		HepG2			[48]
miR-224-5P		3 T3-L1			[49]
miR-19b-3p		CaCO₂	Suppression the expression of ACSL4		[50]
miR-130a-3p
miR-150-5p
miR-144-3p
miR-16-5p
miR-7a-5p
miR-17-5p
MiR-206	ROS	Adult mongrel dogs	Increased the production of ROS by targeting SOD1	Promote	[51]
miR-155		Capan-2, Aspc-1	Increases ROS levels through inhibiting Foxo3a expression	Promote	[52]
miR-25		Rats	Restraining ROS level by targeting NOX4.	Suppress	[53]
miR-448-3p		Mice	Reduced NOX2- dependent ROS production	Suppress	[54]

Back to article page

ISSN: 1756-8722

Contact us

General enquiries: journalsubmissions@springernature.com