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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Fig. 7

Co-targeting CD73 and A2AR shows therapeutic potential in HCC. a Colony formation assays in the indicated HCCLM3 cells. b Apoptosis assays in the indicated HCCLM3 cells. c Tumor growth kinetics in NOG model mice subcutaneously implanted with HCCLM3 cells treated as indicated. d Incidences of lung metastasis of different administered groups versus controls in NOG model mice intravenously injected with HCCLM3 cells. Asterisk indicated P < 0.050 when compared with controls; number sign indicated P < 0.050 when compared with APCP/KW5002 group alone; all in vitro experiments were performed in triplicate; and t tests were used

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Journal of Hematology & Oncology

ISSN: 1756-8722

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