FT | TBF | FLAMSA | p | |
---|---|---|---|---|
Number (total, 856) | 113 | 112 | 631 | |
Follow-up for survivors (months), median (95% CI) | 53 (10–34) | 16 (3–10) | 53 (95% CI 4–35) | < 0.001 |
Age of patient at HSCT (years), median (range) (IQR) | 58 (21–76) (47–64) | 52.1 (24.4–70.1) (38.1–61) | 51.5 (18.1–76) (41.9–59.9) | 0.001 |
Age of patient at HSCT (categorical), n (%) | 0.028 | |||
< 50 years | 35 (31%) | 46 (41%) | 280 (44%) | |
≥ 50 years | 78 (69%) | 66 (59%) | 351 (56%) | |
Gender of patient, n (%) | 0.09 | |||
Male | 66 (59%) | 71 (63%) | 336 (53%) | |
Female | 47 (41%) | 41 (37%) | 295 (47%) | |
Karnofsky performance status at SCT, n (%) | 0.7 | |||
KPS < 80 | 14 (13%) | 12 (11%) | 61 (10%) | |
KPS ≥ 80 | 95 (87%) | 95 (89%) | 523 (90%) | |
Missing | 4 | 5 | 47 | |
Cytogenetics, n (%) | 0.6 | |||
Favorable | 7 (6%) | 2 (2%) | 19 (3%) | |
Intermediate | 37 (33%) | 38 (34%) | 228 (36%) | |
Adverse | 20 (18%) | 19 (17%) | 112 (18%) | |
Missing | 49 (43%) | 53 (47%) | 272 (43%) | |
Disease status, n (%) | 0.2 | |||
Primary induction failure | 73 (64%) | 59 (53%) | 344 (55%) | |
First relapse | 30 (27%) | 44 (39%) | 241 (38%) | |
Second relapse | 10 (9%) | 9 (8%) | 46 (7%) | |
Year of transplant, median (range) | 2011 (2005–2016) | 2015 (2007–2016) | 2010 (2005–2016) | < 0.001 |
Donor, n (%) | 0.06 | |||
MSD | 56 (49%) | 54 (48%) | 252 (40%) | |
UD 10/10 | 44 (39%) | 35 (31%) | 268 (42%) | |
UD 9/10 | 13 (12%) | 23 (21%) | 111 (18%) | |
Donor/recipient sex mismatch, n (%) | 0.8 | |||
F to M | 19 (18%) | 21 (19%) | 124 (20%) | |
No F to M | 87 (82%) | 91 (81%) | 490 (80%) | |
Stem cell source, n (%) | < 0.001 | |||
BM | 4 (4%) | 19 (17%) | 15 (2%) | |
PBSCs | 109 (96%) | 93 (83%) | 616 (98%) | |
CMV donor/recipient, n (%) | < 0.001 | |||
Donor−/Recipient− | 22 (21%) | 13 (12%) | 167 (27%) | |
Donor+/Recipient− | 9 (8%) | 8 (7%) | 76 (12%) | |
Donor−/Recipient+ | 21 (19%) | 25 (23%) | 140 (23%) | |
Donor+/Recipient+ | 57 (52%) | 61 (58%) | 229 (37%) | |
ATG used, n (%) | < 0.001 | |||
No | 69 (61%) | 46 (42%) | 73 (12%) | |
Yes | 44 (39%) | 64 (58%) | 554 (88%) |