Table 2 CircRNAs in acute myeloid leukemia

f-circPR

↑in NB4 cells

Promote proliferation and colony formation of leukemia cells

f-circM9

↑in THP-1 cells and K562 cells

Promote proliferation and colony formation of leukemia cells; knockout of f-circM9 increased apoptosis of THP1

hsa_circ_0075001

↑in AML(M0 or M1)↓in AML(M2, M4 and M5)

Hsa_circ_0075001 expression relates positively to total NPM1 expression, independent of the NPM1 mutational status; high hsa_circ_0075001 expression decreased expression of components of the Toll-like receptor signaling pathway

circ-ANAPC7

↑in AML patients BM

miR-181 family

Unknown

circ-100290

↑in BM cells from AML patients and AML cell lines

miR-203

Increase cell proliferation and inhibited apoptosis via interacting with miR-203/Rab10 axis

circPAN3

↑ircPAN3138" \o "Fan H, 2018 #193" or>Fan H</Author><

↑ircPAN3138" \o "Fan H, 2018 #193" or>Fan H</Author><Year>2018

miR-153-5p

miR-183-5p

XIAP

Downregulation of circPAN3 by siRNA restores ADM sensitivity of THP-1/ADM cells depend on miR-153-5p/miR-183-5p-XIAP axis

circ_0009910

↑irc_000perients BM

miR-20a-5p

Promoted cell proliferation, inhibited apoptosis and predicted adverse prognosis

circ-HIPK2

Mutation of HIPK2 in AML and MDS

Impair AML1- and p53-mediated transcription

↓in APL patients PB and NB4 cells

miR-124-3p

Influence ATRA-induced differentiation of APL cells

circ-DLEU2

↓in pediatric AML-M5

Hypermethylation of DLEU2 affected prognosis

↑in CN-AML patients BMand AML cell lines

miR-496

Promote AML cells proliferation and inhibited cell apoptosis and AML tumor formation in vivo via suppressing miR-496 and promoting PRKACB expression

has_cir_0004277

↓in mononuclear cells from AML patients BM

Increasing level of hsa_circ_0004277 is associated with chemotherapy

circPVT1

Overexpression in AML-amp

Unknown