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Table 3 lncRNAs in acute myeloid leukemia

From: Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

lncRNAs

Altered expression

Targets

Function

Reference

PVT1

↑in AEL/APL

 

Protect MYC from degradation to promoted promyelocytes proliferation

[163]

CRNDE

↑in AML cell lines

 

Promote cell proliferation and arrest cell cycle in G0-G1 phase

[168]

MEG3

↓in AML

 

Promote AML leukemogenesis

[172]

CCD26

↑in NPM1-mutated AML

c-Kit

Control the growth of AML cells

[176]

H19

↑in AML-M2 patients

has-miR-19a/b

Regulated the expression of ID2 through competitive binding to miR-19a/b to increase cells proliferation

[186]

NEAT1

↓in AML blood sample and AML cell lines

miR-23a-3p

Increase myeloid cell proliferation and ATRA-induced myeloid differentiation, and induce apoptosis

[187]

UCA1

↑in AML cell lines and CN-AMLwith biallelic CEBPA

miR-126, RAC1

Increased cell proliferation, inhibited apoptosis, migration, and invasion by sponging miR-126

[188]

↑in AML cell lines and CN-AML with biallelic CEBPA

p27kip1

Role in promoting cells proliferation is to sequester hnRNP I to inhibit the expression of the cell cycle regulator p27kip1

[167]

↑in HL-60 and HL-60/ADR

miR-125a

Poor chemotherapy overcome

[189]

HOTAIR

↑in de novo AML patients

miR-193a;c-Kit

Increase AML cells proliferation, inhibited apoptosis and infiltration of leukemic blasts and number of AML cells colony formation, and shorten overall survival time

[190]

↑in LSC

p15

Promote the self-renewal of leukemia stem cells

[191]

CCAT1

↑in HL60 and AML PB

miR-155, c-Myc

Upregulated c-Myc expression to increased cells proliferation and differentiation by its competing endogenous RNA (ceRNA) activity on miR-155

[192]

FTX

↑in U937 and THP-1

miR-342, ALG3

Drug resistance

[193]

PANDAR

↑ANDARLINK

 

Predict adverse prognosis in AML

[181]

HOXA-AS2

↑in APL

TRAIL-mediated pathway

Lead to fine-tuning of apoptosis during ATRA-induced myeloid differentiation

[194]

↑00PERLINK \l "_ENREF_200" \o "Zhao H, 2013 #197" or><adriamycin-based chemotherapy and in U/A and T/A cells

miR-520c-3p/S100A4 Axis

Knockdown of lncRNA HOXA-AS2 inhibited ADR cell proliferation and chemoresistance of AML by the miR-520c-3p/S100A4 Axis, and promoted apoptosis

[195]

HOTAIRM1

↑in AML cell lines

HOXA1, HOXA4, CD11b,CD18,miR-20a/106b

miR-125b

Regulate myeloid cell differentiation and cell cycle via enhancing the autophagy pathway and PML-RARα degradation

[161]

[196] [197] [198]

IRAN

↑in AML

IGF1R

long-range DNA interactions

[199]

RUNXOR

↑in AML

RUNX1

Participate in chromosomal translocation

[200]

ANRIL

↑in AML patients at diagnosis

↓in patients after CR

ANRIL/AdipoR1/AMPK/SIR pathway

Promote cell survival

[201]

vtRNA2-1

  

Regulate pPKR

[202]

linc-223

↓in AML cell lines

IRF4; miR-125-5p

Control proliferation and differentiation of AML cells and IRF4 downregulation by binding miR-125-5p

[203]

LINC00899

↑INC00899K \l "_ENREF_13patients

 

As a novel serum biomarker for diagnosis and prognosis of AML

[204]

  1. Abbreviations: CR complete remission, PB peripheral blood, CN-AML cytogenetically normal AML, (U/A) U937/ADR cell, (T/A) THP-1/ADR cell