Fig. 5
From: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer
LXY30 activates EGFR and its downstream signaling molecules independently from another integrin ligand LXW64. Schematic representation for the cross talk between integrin and EGFR is illustrated (a). The effect of LXY30 and/or LXW64 on the expression of integrin subtypes, EGFR, and its key downstream signaling molecules in H1975 (EGFR L858R/T790 M) cells was analyzed after incubating with LXY30-biotin, LXW64-biotin, or LXY30-biotin/LXW64-biotin for 72 h by Western blot (b) and subsequently quantified (c). *p < 0.01