Fig. 7
From: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer
Optical images showing preferential uptakes of LXY30-biotin-streptavidin-Cy5.5 conjugate (i.e., drug surrogate) in EGFR-resistant lung cancer xenografts in nude mice. After conjugated with streptavidin-Cy5.5, LXY30 shows the capability to deliver imaging dye to subcutaneous xenografts of H1975 (a, c) and A549 (b, d). Representative images of tumor sections were stained by H&E staining (e, f), fluorescent (Alexa 594)-labeled anti-α3 integrin antibody (g, h), and integrin α3 IHC (i, j). *p < 0.05