Immune cell therapy for hepatocellular carcinoma

Table 1 Cytotoxic T cell epitopes expressed in hepatocellular carcinoma and their T cell receptors

Antigen	Frequency of occurrence (%)	Cytotoxic T cell epitope	HLA restriction	Year of report	Reporter [reference]	T cell receptor*	Year of report	Reporter [reference]
AFP	< 80	AFP₁₃₇, AFP₁₅₈	A2	1999	Butterfield et al. [10]	AFP₁₅₈	2018	Docta et al. [26]
AFP	< 80	AFP₃₂₅, AFP₅₄₂, AFP₃₅₇, AFP₄₀₃	A24	2006	Mizukoshi et al. [14]	AFP₃₅₇	2017	Nakagawa et al. [27]
NY-ESO-1	< 50	NY-ESO-1₁₅₇	A2	2004	Korangy et al. [11]	NY-ESO-1₁₅₇	2014	Robbins et al. [28]
MAGE-A	< 80	MAGE-1₁₆₁, MAGE-3₂₇₁	A1, A2	2004	Zerbini et al. [12]
MAGE-A	< 80	MAGE-10₂₅₄	A2	2005	Bricard et al. [13]
SSX-2	< 50	SSX-2₄₁	A2	2005	Bricard et al. [13]
hTERT	< 80	hTERT₁₆₇, hTERT₃₂₄, hTERT₄₆₁, hTERT₆₃₇, hTERT₈₄₅	A24	2006	Mizukoshi et al. [15]	hTERT₄₆₁	2015	Mizukoshi et al. [29]
Glypican-3	< 70	GPC3₁₄₄, GPC3₂₉₈	A2, A24	2006	Komori et al. [16]	GPC3₃₆₇	2015	Dargel et al. [30]
p53	100	p53₁₄₉, p53₂₆₄	A2	2006	Cicinnati, et al. [25]
HCA661	Unknown	HCA661₁₁₀, HCA661₂₄₆	A2	2007	Pang et al. [17]
MRP3	< 55	MRP3₅₀₃, MRP3₆₉₂, MRP3₇₆₅	A24	2008	Mizukoshi et al. [18]
HCA587	< 70	HCA587₁₄₀, HCA587₁₄₄, HCA587₂₄₈	A2	2008	Xing et al. [19]
SART2	100	SART2₉₃, SART2₁₆₁, SART2₈₉₉	A24	2012	Mizukoshi et al. [20]
SART3	100	SART3₁₀₉, SART3₃₁₅	A24	2017	Kaji et al. [21]

AFP alpha-fetoprotein, MAGE melanoma-associated antigen, SSX-2 synovial sarcoma/X breakpoint-2, hTERT human telomerase reverse transcriptase, HCA hepatocellular carcinoma-associated antigen, SART squamous cell carcinoma antigen recognized by T cell
*The epitopes recognized by cytotoxic T cell receptor were described

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