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Table 1 Cytotoxic T cell epitopes expressed in hepatocellular carcinoma and their T cell receptors

From: Immune cell therapy for hepatocellular carcinoma

Antigen Frequency of occurrence (%) Cytotoxic T cell epitope HLA restriction Year of report Reporter [reference] T cell receptor* Year of report Reporter [reference]
AFP < 80 AFP137, AFP158 A2 1999 Butterfield et al. [10] AFP158 2018 Docta et al. [26]
AFP325, AFP542, AFP357, AFP403 A24 2006 Mizukoshi et al. [14] AFP357 2017 Nakagawa et al. [27]
NY-ESO-1 < 50 NY-ESO-1157 A2 2004 Korangy et al. [11] NY-ESO-1157 2014 Robbins et al. [28]
MAGE-A < 80 MAGE-1161, MAGE-3271 A1, A2 2004 Zerbini et al. [12]    
MAGE-10254 A2 2005 Bricard et al. [13]
SSX-2 < 50 SSX-241 A2 2005 Bricard et al. [13]    
hTERT < 80 hTERT167, hTERT324, hTERT461, hTERT637, hTERT845 A24 2006 Mizukoshi et al. [15] hTERT461 2015 Mizukoshi et al. [29]
Glypican-3 < 70 GPC3144, GPC3298 A2, A24 2006 Komori et al. [16] GPC3367 2015 Dargel et al. [30]
p53 100 p53149, p53264 A2 2006 Cicinnati, et al. [25]    
HCA661 Unknown HCA661110, HCA661246 A2 2007 Pang et al. [17]    
MRP3 < 55 MRP3503, MRP3692, MRP3765 A24 2008 Mizukoshi et al. [18]    
HCA587 < 70 HCA587140, HCA587144, HCA587248 A2 2008 Xing et al. [19]    
SART2 100 SART293, SART2161, SART2899 A24 2012 Mizukoshi et al. [20]    
SART3 100 SART3109, SART3315 A24 2017 Kaji et al. [21]    
  1. AFP alpha-fetoprotein, MAGE melanoma-associated antigen, SSX-2 synovial sarcoma/X breakpoint-2, hTERT human telomerase reverse transcriptase, HCA hepatocellular carcinoma-associated antigen, SART squamous cell carcinoma antigen recognized by T cell
  2. *The epitopes recognized by cytotoxic T cell receptor were described