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Fig. 10 | Journal of Hematology & Oncology

Fig. 10

From: Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway

Fig. 10

Schematic presentation of the anti-TNBC mechanism of Ilamycin C. The inhibition of IL-6 induced JAK2/STAT3 phosphorylation by Ilamycin C abrogates the function of p-STAT3 through decreasing the level of p-STAT3 in the nucleus, thus further regulating the expressions of its downstream target genes, which ultimately contributed to promote Bax/Bcl-2-related caspase-dependent apoptosis and suppress migration and invasion through MMP2/MMP9/vimentin/fascin in TNBC cells

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Journal of Hematology & Oncology

ISSN: 1756-8722

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