Fig. 7
From: The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy
A schematic showing the involvement of H19 in tamoxifen resistance in breast cancer. When H19 is absent (left panel), SAHH hydrolyzes SAH, which causes DNMT3B-facilitated methylation in the promoter region of Beclin1; however, when H19 inhibits SAHH (right panel), it results in the accumulation of SAH, which restricts DNMT3B from methylating the promoter region of Beclin1. The increased expression level of Beclin1 subsequently initiates autophagy, conferring tamoxifen resistance in ER-positive breast cancer