Fig. 4
From: Noncoding RNAs in cancer therapy resistance and targeted drug development
Schematic illustration of the delivery strategies of ncRNAs in cancer therapy. a SiRNA, ASOs, saRNA, and miRNA can be encapsulated inside the LNP to be protected from biological conditions and delivered into cancer cells. b SiRNA is chemically conjugated with carriers forming carrier-siRNA conjugates. c SAMiRNA, the siRNAs are modified with lipid and PEG molecules, and then self-assembled lipid nanoparticles. d ShRNA and sgRNA can be delivered by oncolytic adenovirus-mediated strategy and achieve a long-lasting expression of ncRNA in cancer cells.