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Table 1 Ongoing clinical trials of non-coding RNAs in cancer (ClinicalTrials.gov)

From: Noncoding RNAs in cancer therapy resistance and targeted drug development

NcRNA

NCT number

Clinical trials

Cancer

Phases

miR-31

miR-210

NCT03684707

Cancer chemoprevention by metformin hydrochloride compared to placebo in oral potentially malignant lesions

Oral cancer

Phase 4

miR-31-3p

miR-31-5p

NCT03362684

PETACC-8 miR-31-3p and miR-31-5p ancillary study

Colorectal Cancer

Phase 3

miR-34a

NCT02862145

Pharmacodynamics study of MRX34, microRNA liposomal injection in melanoma patients with biopsy accessible lesions

Melanoma

Phase 1

Phase 2

miR-34a

NCT01829971

A multicenter phase I study of MRX34, microRNA miR-RX34 liposomal injection

Primary liver cancer, SCLC, lymphoma, multiple myeloma, renal cell carcinoma

Phase 1

miR-10b

NCT01849952

Evaluating the expression levels of microRNA-10b in patients with gliomas

Glioma

Recruiting

miR-29b

NCT02009852

Observational study to explore the prognostic value of miR-29b in tissue, blood, and saliva

Oral cancer

Recruiting

miR-29 family

NCT01927354

Observational study to investigate the role of microRNA in Twist1-mediated cancer metastasis

Head and neck squamous cell carcinoma

Recruiting

miRNA-100

NCT02950207

Prospective observational study of antitumor activity correlation between hormonal therapy and expression miRNA100

Breast cancer

Recruiting

MiR-155

NCT03591367

The potential role of microRNA-155 and telomerase reverse transcriptase in diagnosis of non-muscle invasive bladder cancer and their pathological correlation

Bladder cancer

Recruiting

miR-16

NCT02369198

MesomiR 1: a phase I study of TargomiRs as 2nd or 3rd line treatment for patients with recurrent MPM and NSCLC

Malignant pleural mesothelioma, non-small cell lung cancer

Phase 1

miR-21

miR-20a-5

miR-103a-3p

miR-106b-5p

miR-143-5p

miR-215

NCT02466113

A 6 microRNA tool for stratifying stage II colon cancer of receiving adjuvant chemotherapy

Colon cancer

Recruiting

miR-221

miR-222

NCT02928627

Clinical significance of hepatic and circulating microRNAs miR-221 and miR-222 in hepatocellular carcinoma

Hepatocellular carcinoma

Recruiting

miR-122

NCT03687229

The effect of DAAs on miRNA-122 and insulin resistance in chronic HCV patients

Chronic hepatitis C, hepatocellular carcinoma

Not yet recruiting

MiR-25

NCT03432624

Detection of microRNA-25 in the diagnosis of pancreatic cancer

Carcinoma, pancreatic ductal

Not yet recruiting

HOTAIR

NCT03469544

Long non-coding RNA HOTAIR and Midkine as biomarkers in thyroid cancer

Thyroid cancer

Recruiting

THRIL,PACER

NCT03057171

A study on the gastrointestinal disease and helicobacter pylori controlled long non-coding RNA

Stomach cancer

Recruiting