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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

Fig. 1

Comparing the inhibitors tackling the differentiation blockage in AML. a Proliferation inhibition effect of BAY-155, OTX015, EPZ-5676, BAY 1251152, and Brequinar in MV4-11, MOLM-13 and HL-60 cells after 4 days of treatment. Vehicle control (DMSO) of each cell line is set to 100%. Representative experiment of at least 3 biological replicates is shown. b Quantification of CD11b expression after BAY-155, OTX015, EPZ-5676, BAY 1251152, and Brequinar in MV4-11, MOLM-13, and HL-60 cell lines after 4 and 7 days of treatment detected with flow cytometry. Data represents median values from 10,000 living cells normalized to vehicle control (DMSO). c Wright-Giemsa-stained cytospins of MV4-11, MOLM-13, and HL-60 cells after 7 days of treatment with BAY-155 (0.05 μM, 0.5 μM, 2.5 μM, respectively), OTX015 (0.1 μM, 0.1 μM, 0.25 μM, respectively), EPZ-5676 (0.4 μM, 1 μM, 10 μM, respectively), BAY 1251152 (0.05 μM, 0.05 μM, 0.05 μM, respectively), and Brequinar (0.1 μM, 0.3 μM, 1 μM, respectively). In the top right corner of each image magnification of representative cells are shown. Black scale bar indicates 10 μm

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