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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

Fig. 3

Gene set enrichment and principal component analyses. a Heatmap representing enrichment scores (NES) of different gene sets in GSEA. Yellow star indicates significant enrichment. b Analysis of logFC gene expression of indicated MLL target genes. Data is normalized to corresponding DMSO control and cell models are grouped based on their respective IC50 values. c Scores plot of the PCA based on the top thousand most variable genes in AML cell lines. Data adjusted to gene expression in vehicle (DMSO). d Loadings plot corresponding to the plot in c. Genes associated with AML differentiation are highlighted

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