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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Target selection for CAR-T therapy

Fig. 1

Schematic description of the expression of CD19 and CD22. a The expression patterns of CD19 and CD22 during B cell development. b Gene mutation is the main mechanism of antigen-negative relapse after CAR-T-19 treatment. This picture is quoted from an article published in Nature Medicine by Orlando et al. in 2018 [27]. c Silence of expression, rather than gene mutation, is the main cause of CD22 loss after CAR-T treatment. This picture is quoted from an article published in Nature Medicine by Fry et al. in 2018 [28]

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