Fig. 2From: Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applicationsTumor-associated macrophages (TAMs) polarization and its regulatory networks. Polarization of TAMs is regulated by multiple microenvironmental cytokines, growth factors, epigenetic regulators, and other signals derived from tumor and stromal cells. Two types of macrophages (M1/M2) secrete different immune markers, metabolic characteristics, and gene expression profiles to exert different functionsBack to article page